Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected ?-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands

In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes general formula [Ru(?6-p-cymene)(X,Y)(Z)] prepared, where (X,Y) represents either an O,O-ligand (?-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) Cl? 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested inhibit chlamydial growth on HeLa cells, one inhibits human herpes simplex virus-2. chlorido N,O- O,S-ligands displayed strong antibacterial activity Gram-positive strains including resistant S. aureus (MRSA) cytotoxic adenocarcinoma cell lines. Effect structural variation properties solution was clearly revealed. decreased bioactivity ?-diketone can be related lower solution. contrast, are highly stable complexation prevents oxidation O,S-ligands. Comparing binding PTA co-ligands, it concluded that is generally more strongly coordinated ruthenium, which at same time serum albumin 1-methylimidazole well diminished bioactivity.